Type 2 Diabetes (T2D) is the main epidemic of this century. A recent hypothesis of medical research is that an ​important cause of T2D may be the abnormal regulation of glucose absorption in the small intestine​. The objective of the present project is to start the validation of this hypothesis based on formal computational models enhanced by wet-lab experiments. The hope is to improve the identification of the causes of T2D and, in the longer run, the prediction of appropriate therapies based on such models.