Logistic systems represent a competitive advantage that companies seek to perpetuate. They aim to optimize the different flows that the company has with its suppliers and customers. The current environment, in which logistic systems evolve, is dominated by the uncertainty and dynamicity. Therefore incorporate uncertainty and dynamic character as parameters in the reasoning of the decision-maker has become a major industrial challenge that can limit the vulnerability of logistic systems. In this context, the OSL team studies and develops new specific models and optimization methods for logistic systems to make them effective. Logistic systems studied by the OSL team concern production, transport, healthcare and crisis management.